Letters to the Editors.

نویسندگان

  • Steve Black
  • Henry Shinefield
چکیده

The oxidation-reduction potential of cozymase (diphosphopyridine nucleotide) was calculated from the free energies of formation of aqueous d-alanine and d-glutamic acid based on thermal data, and the equilibria measured by Wurmser and Filitti-Wurmser’ for pyruvate + 2H+ + 2(e) + alanine + HzO, by Cohen2 for a-ketoglutarate + alanine s d-glutamate and pyruvate, and by von Euler et aLa for the reaction cu-ketoglutarate +NHt + reduced cozymase + glutamate + oxidized cozymase. The value for the potential so calculated is at 30” E’o = -0.072 0.03 pH f 0.0008 volt. Its temperature coefficient is Ai?/AT = -0.00043, calculated from the data given by von Euler, Adler, Gunther, and Hellstrom and by Barron and Hastings.s As a check on the accuracy of this calculated value of B it was used to calculate -AP for the reaction acetaldehyde (aqueous) + 2H+ + 2(e) --f ethyl alcohol (aqueous) from the equilibrium constant for acetaldehyde + reduced cozymase $ ethyl alcohol + oxidized cozymase determined by Negelein and W~lff.~ This constant (corrected for temperature) and the above value of B give -AP for acetaldehyde -+ alcohol at 25” as 11,620 calories. -AP calculated from the best thermal and ancillary data is 11,730 calories.

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عنوان ژورنال:
  • The Pediatric infectious disease journal

دوره   شماره 

صفحات  -

تاریخ انتشار 2008